Samuel Lisle Lightfoot
- Born: 17 November 1805, Norfolk, Norfolk, Virginia, United States
- Marriage (1): Mary Frances Columbia Lee on 11 January 1827 in Norfolk, Norfolk, Virginia, United States
- Died: 16 August 1855, , Norfolk, Virginia, United States at age 49
- Buried: After 16 August 1855, Cedar Grove Cemetery, Norfolk, Virginia, United States
Samuel married Mary Frances Columbia Lee on 11 January 1827 in Norfolk, Norfolk, Virginia, United States. (Mary Frances Columbia Lee was born in 1809 and died in 1888.)
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